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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-let-7b
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples, normal retinas
Methods microarray, qRT-PCR
Expression pattern down-regulated
Functional description let-7b was on average B50-fold lower in abundance in retinoblastoma versus healthy retina. This downregulation is widespread across retinoblastoma; 9/10 of these samples from different individuals had lower let-7b levels than the average let-7b expression in five retina samples from healthy individuals.
PubMed ID 18026111
Year 2007
Title Using expression profiling data to identify human microRNA targets.
Drug-related ncRNA NO

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